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Prof. Dr. Haike Antelmann


New address:

Freie Universität Berlin
Institut für Biologie-Mikrobiologie
Königin-Luise-Straße 12-16
D-14195 Berlin
Germany
Phone: +49-30-838-51221
Fax: +49-30-838-451221
E-mail: » haike.antelmann@fu-berlin.de

Research interests and expertises :
My research focus are the molecular mechanisms of oxidative and electrophilic stress responses in Gram-positive bacteria. We investigate the changes in the transcriptome and post-translational thiol-modifications caused by ROS and RES in Gram-positive bacteria in the thiol-redox proteome and the regulatory mechanisms of novel redox-sensing regulators. Most recent research involves the physiology and thiol-modifications caused by bacillithiol and mycothiol in different Gram-positive bacteria. We found that bacillithiol and mycothiol play important roles in redox regulation and protection of essential and conserved proteins against irreversible oxidation by protein S-bacillithiolation and protein S-mycothiolation. Future studies involve the investigation of the physiological roles and impact for virulence mechanisms of these thiol-modifications in pathogenic Gram-positives.


Publications about protein S-thiolations and bacilliredoxins :

Chi, B.K., Roberts, A., Huyen,T.T.T., Gronau, K., Becher, D., Albrecht, D., Hamilton, C. and Antelmann*, H. 2013. S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria. Antioxidants & Redox signaling 18: 1273-1295. » [link]

Gaballa, A., Chi, B.K., Roberts, A.A., Becher, D., Hamilton, C., Antelmann, H.* and Helmann, J.D.* 2014. Redox regulation in Bacillus subtilis: the bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE. Antioxidants & Redox Signaling, doi:10.1089/ars.2013.5327. » [link]

Chi, B. K., Busche. T., Van Laer, K., Bäsell, K., Becher, D., Clermont, L., Seibold, G., Persicke, M., Kalinowski, J., Messens, J. and Antelmann, H.* 2014. Protein S-mycothiolation functions as redox-switch and thiol protection mechanism in Corynebacterium glutamicum under hypochlorite stress. Antioxidants & Redox Signaling, doi:10.1089/ars.2013.5423. » [link]